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At what point does GPA start to hurt your medical school applications?

If you go to a top 20 school, a common belief is that while you will probably not get a 4.0 like you could at a state school/flagship, getting at least a certain GPA will not adversely affect your medical school application (at least at my school). Assuming you're interested in a top medical program, at what point does having a lower GPA have a neutral/harmful effect (ie a 3.X is basically a 4.0, at what point is this not true?) How low should your GPA be for you to consider transferring to either a state flagship or a school known for grade inflation (like Brown)? What about switching majors? How helpful is a STEM major vs something like econ (I hear major difficulty is not very helpful)

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